GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2243480 | 1 | rs781150 | chr7:65480973 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.4 | 1.43E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs781156 | chr7:65479141 | CCT6P1 | chr7:65216092-65228661:+ | 0.31 | 4.42 | 1.31E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs781157 | chr7:65478311 | CCT6P1 | chr7:65216092-65228661:+ | 0.3 | 4.34 | 1.8E-5 | Diabetic kidney disease |
| BLCA | cis | rs6951245 | 1 | rs78143408 | chr7:1096846 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs78153629 | 1 | rs78153629 | chr15:40673465 | C15orf23 | chr15:40674922-40686488:+ | 0.32 | 5.57 | 4.84E-8 | Heschl's gyrus morphology |
| BLCA | cis | rs6951245 | 1 | rs78158942 | chr7:1090440 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.5 | 9.13E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs78185558 | chr7:1090183 | ZFAND2A | chr7:1192544-1199855:- | -0.36 | -4.28 | 2.39E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs6951245 | 1 | rs78185801 | chr7:1096367 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.41 | 1.33E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs3829251 | 1 | rs78300366 | chr11:71205514 | KRTAP5-10 | chr11:71276609-71277666:+ | 0.2 | 3.86 | 0.000135 | Vitamin D levels |
| BLCA | cis | rs6951245 | 1 | rs78308415 | chr7:1072634 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.37 | 1.6E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs11723261 | 1 | rs78343340 | chr4:267437 | ZNF718 | chr4:53272-156488:+ | 0.35 | 4.72 | 3.37E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs6951245 | 1 | rs78523927 | chr7:1089458 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.5 | 9.13E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs2275426 | 1 | rs785464 | chr1:46523089 | CCDC163P | chr1:45960581-45965646:- | -0.33 | -6.25 | 1.1E-9 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs785471 | chr1:46518677 | CCDC163P | chr1:45960581-45965646:- | -0.33 | -6.14 | 2.02E-9 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs785479 | chr1:46492144 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.89E-10 | Body mass index |